The first part of the course deals with the biomolecule (DNA, proteins) structure and the quantitative assessment of biomolecule/ligand interactions (parameters, measurements, biophysical techniques). A second part presents the development of biologically/therapeutically active metallic complexes. Several roles or activities of the metal center are presented: purely structural role (e.g., enzyme inhibition or protein-protein interactions), ligand exchange effects (DNA-platinum complexes, release of small molecules like CO, and so on), redox activity (ferrocifene, Pt(IV) complexes, catalytically active complexes), and so on.
Language course: English
Credits ECTS: 4
- Teaching coordinator: François Ozanam